AIRE

Adaptation, Integration, Reticulation, Evolution

We're Hiring !

We are currently looking for two motivated postdoctoral students who wish to join the Bapteste/Lopez lab in 2021/2022/2023.

If you're interested, read more here !

About us

The team "Adaptation, Integration, Reticulation and Evolution" studies evolution, and develops new methods of tree forests and evolutionary networks construction and comparison to represent, characterize and analyze evolutionary processes in prokaryotes, eukaryotes and mobile elements. Our works are inspired by some simple ideas:

  • The study of the single genetic content of microbial chromosomes is not sufficient to study all of the natural genetic diversity. Much, if not most, of genetic diversity is carried by mobile genetic elements, in permanent transit between cells;
  • DNA molecules are exchanged and transformed through interactions between partners that are not necessarily related but belong to a larger genetic community;
  • Genetic chimeras are particularly numerous in nature because of lateral exchanges that add to the process of vertical inheritance and replication.
  • The inclusion of as much environmental data (metagenomic) and mobile element sequences (phage, plasmids) as possible in evolutionary analyzes is essential to complement traditional phylogenetic and phylogenetic approaches, and to delve deeper into some of them.

In the past ten years, the AIRE Team has developed sequence similarity networks (SSN), a powerful inclusive scalable network-based approach to structure and analyse the evolution of genetic diversity, at multiple levels of biological organisation.

These original methodological developments now allow us to propose and implement a new research approach: the coupling of phylogenomics, interaction networks and Sequence Similarity Networks to develop a new type of evolutionary analyses, that we call phylosystemics or evosystemics. Phylosystemics uses evolutionary labeled interaction networks to model the evolution of biological organisations and of biological processes, and to better explain the evolution of biological complexity and diversity by retracing interactions between phylogenetically related or unrelated components.

Currently, the AIRE Team uses phylosystemics to describe (micro)biological evolution from an increasingly systemic perspective

The EVOLUNET project

The EVOLUNET project is supported by the European Research Council under the European Community’s Seventh Framework Programme (FP7/2007-2013 Grant Agreement # 615274, category LS8).
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Latest News

11 September 2020
05 December 2018
05 December 2018
12 November 2018

Contact Us

UMR 7205 ISYEB
Campus Jussieu
Bâtiment A, 4eme et. pièce 429
Sorbonne Université
75005 Paris - France

Phone: +33144273470
 

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